Multi-reader study included 74 consecutive patients (median age = 66 years, [IQR = 57.25–71.75 years]; median PSA = 4.30 ng/mL [IQR = 1.33–7.75 ng/mL]) with suspected or confirmed PCa, who underwent mpMRI between October 2023 and January 2024. Here, KLK3 is linked to posterior cortical atrophy.