TP53 and cancer: As an important member of the deubiquitinase family, USP5 has been suggested to be an oncoprotein in several types of cancer, involved in regulating the stability of proteins in some oncogenic signaling pathways.34–39 For example, USP5 may stabilize the ERK signaling, which governs the PD-1 homeostasis via deubiquitination, and thus influences cancer immunotherapy outcomes.39 The USP5–Beclin1 axis has been reported to override p53-dependent senescence, promoting Kras-induced lung tumorigenicity in mice.35 However, the role of USP5 in tumor angiogenesis is rarely known.