TBX21 and neoplasm: Transfer of Tbet−/− Treg cells to leukemic mice results in significantly higher frequencies of BM-infiltrating ST2+ Treg cells than mice that receive WT Treg cells or ST2−/− Treg cells or no tumor (P = 0.005, P < 0.0001 and P < 0.0001, respectively) (Fig. 5E).