With the development of AML, the frequency of WT1-tetramer+ CD8 T cells progressively increases in the BM of both Foxp3Cre and Foxp3CreST2fl/fl mice, but much higher numbers are found in the BM of Foxp3CreST2fl/fl mice (Fig. 5G). The gene discussed is CD8A; the disease is acute myeloid leukemia.