Drivers of functional changes in Treg cells (LAG3, TIM3, and GITR) are also expressed at higher levels in ST2+ Treg cells versus ST2− Treg cells from the malignant BM niches (Fig. 2D, MLL-AF9 leukemia; Supplementary Fig. 7C, E, DNMT3A/FLT3ITD leukemia). The gene discussed is IL1RL1; the disease is leukemia.