The PT cluster expresses early and mature markers such as CDH6, PDZK1, LRP2, and SLC3A1, whereas the early and mature distal clusters are mainly distinguished by downregulation of TFAP2B and upregulation of MUC1 and CDH1. Interestingly, the DT/CNT-DAPT cluster differentially expresses PROM1 (CD133), a marker of clonal cell proliferation in the adult (Osnat et al, 2020; Bussolati et al, 2005) and fetal kidney (Pode-Shakked et al, 2016, 2017) that was recently associated with an adaptive state following kidney injury (Lake et al, 2023) (Fig. EV9C). This evidence concerns the gene PDZK1 and medical procedure.