Furthermore, LNCaP with FOXA2 OE grew xenograft tumors much more rapidly than the control cells, showing mixed adenocarcinoma to small-cell carcinoma histology and strong synaptophysin (SYP) staining that closely recapitulated treatment-induced NEPC in patients (Extended Data Fig. 2d–f and Supplementary Note 1). This evidence concerns the gene FOXA2 and small cell carcinoma.