Significant variants also included MST1R*rs3733134 (EUR meta-analysis P = 1.4 × 10−17; cross-ancestry meta-analysis P = 6.9 × 10−18), EXD2*rs4899292 (EUR meta-analysis P = 1.7 × 10−16; cross-ancestry meta-analysis P = 3.8 × 10−16), LONRF2 and SLC39A8. SLC39A8 was previously associated with several psychiatric disorders, including problematic alcohol use36, schizophrenia37 and opioid use disorder38 (Supplementary Discussion). The gene discussed is LONRF2; the disease is psychiatric disorder.