Significant variants also included MST1R*rs3733134 (EUR meta-analysis P = 1.4 × 10−17; cross-ancestry meta-analysis P = 6.9 × 10−18), EXD2*rs4899292 (EUR meta-analysis P = 1.7 × 10−16; cross-ancestry meta-analysis P = 3.8 × 10−16), LONRF2 and SLC39A8. SLC39A8 was previously associated with several psychiatric disorders, including problematic alcohol use36, schizophrenia37 and opioid use disorder38 (Supplementary Discussion). This evidence concerns the gene EXD2 and psychiatric disorder.