This approach highlighted SNPs mapping to SOD1 (cytogenic band 21q22.11), found in the region of APP (21q21.3), with lead SNPs from NNs around 5 Mb away from the closest NN-based hits in APP. SOD1 has been widely investigated for its role in antioxidant defense system, showing impaired expression in AD patients40,41, but is currently primarily implicated in ALS. This evidence concerns the gene APP and Alzheimer disease.