RELA and neoplasm: Activation of the IKK complex results in phosphorylation of the inhibitory protein IkB, followed by its ubiquitination and degradation in the proteasome, allowing NF-κB p65 (RelA)/p50 to migrate to the nucleus and induce the expression of IFNB1 but also proinflammatory cytokines such as Interleukin 6 (IL-6) that can promote tumor proliferation [10, 12, 13] and immune evasion [14].