HIF1A and colitis: To investigate the role of HIF-1α in mice with acute colitis, the mice were intraperitoneally injected with a HIF-1α stabilizer (Dimethyloxallyl Glycine, DMOG) or a HIF-1α inhibitor (2-Methoxyestradiol, 2-ME2) to assess the general conditions and intestinal barrier function (Fig. 5A).