The involvement of p66Shc in various cancer signalling systems, including cell survival and proliferation through PI3K/Akt, MAPK and mTOR, apoptosis regulation, inflammation and immune response by NF‐κB, development and differentiation with TGF‐β, cell cycle regulation and stress response represents a central role in oncogenic signalling networks [4]. This evidence concerns the gene AKT1 and cancer.