Additional AD risk genes uniquely identified by MTSG include BCL3 (P-value: 4.191 × 10-25), which is associated with genetic linkage with late-onset familial Alzheimer’s disease [26,31,32]; NECTIN2 (P-value: 3.539 × 10-29), which has strong signals in multiple GWAS and shown to be implicated in the pathology of AD [33]; HIKESHI (P-value: 1.622 × 10-27), which encodes protein Hikeshi, a nuclear import carrier for heat shock protein 70 (HSP70) that inhibits amyloid-β oligomerization, enhances amyloid-β clearance, restores tau homeostasis, and suppresses neuronal apoptosis [34]. Here, HIKESHI is linked to familial Alzheimer disease.