Notably, p53 isoforms exhibit both overlapping and distinct functions compared to canonical p53 (Mehta et al., 2021; Pal et al., 2023; Zhao and Sanyal, 2022) and have been reported to promote tumor progression in various cancers (Vieler and Sanyal, 2018; Zhao and Sanyal, 2022). Here, TP53 is linked to cancer.