LRRK2 and Parkinson disease: Mutations in LRRK2 are identified as causal for PD, and a PPM1H truncating mutation has been identified in a PD case where, upon autopsy, it was found that the postmortem brain contained a cilia phenotype similar to that identified in LRRK2 mutation postmortem brains; Ppm1h KO in mouse shows the same phenotype as hyperactive LRRK2 mutations.27 Therefore, we explored the possibility of a similar genetic link between PPM1M mutations and PD.