LRRK2 pathogenic variants display population-specific frequencies.2,6 The most common global pathogenic LRRK2 variant is G2019S, which increases kinase activity about 2-fold.7LRRK2 G2019S has a high frequency in Ashkenazi Jewish (15%–20%) and North African Arab-Berber (>30%) patients with PD.2,6 Other population-specific variants include LRRK2 R1441G (Basque population, ∼6%)2,6 and R1628P and G2385R (East Asian population, 5%–10% of patients; 2-fold risk increase). Here, LRRK2 is linked to Parkinson disease.