Activation of P2Y12 leads to platelet degranulation which modulates leukocytes for production of proinflammatory cytokines, e.g., IL1β and TNFα, implicated in sepsis4; by contrast, inhibition of P2Y12 decreases cytokines, which in turn could decrease inflammation in patients with CKD.4,5 Therefore, inhibition of P2Y12 may prevent or reduce the severity of sepsis by decreasing the severity of the inflammatory response. The gene discussed is P2RY12; the disease is chronic kidney disease.