Moreover, patients with ESKD treated with intermittent low-dose recombinant IGF-1 had elevated inulin clearance, higher than that achieved with dialysis alone and more than that of the placebo-treated patients.69 However, more attention has been given to IGF-binding proteins (IGFBPs) since they were found to have biologic effects on their own other than regulating the bioavailability of IGF-1.70 IGFBP-2 was found to be a sensitive marker for the severity of nephrotic syndrome in children. The gene discussed is IGF1; the disease is nephrotic syndrome.