Hepatic IGF-1 deficiency was also found to elevate systolic BP in desoxycorticosterone acetate-salt hypertension mice compared with mice with normal IGF-1 levels.68 To differentiate the role of liver IGF-1 from IGF-1 produced locally in the kidney due to high GH in the hepatic IGF-1 KO mice, Nordstrom et al. developed a mouse model that is unable to secrete GH from the pituitary and is deficient in IGF-1 in the liver. This evidence concerns the gene IGF1 and hypertensive disorder.