FGF21 and chronic kidney disease: In CKD mouse model of unilateral ureteral obstruction, increased FGF21 inhibited the Wnt/β-catenin pathway, alleviating renal fibrosis.48 Inflammatory markers, IL-1β and TNF-α, were also reduced by increasing renal FGF21 expression.48 Several reports indicate the benefit of increased circulating or renal FGF21 levels in diabetic nephropathy (DN).