JAK2 and metabolic dysfunction-associated steatohepatitis: The secretion of IGF-1 in the liver is controlled by GH acting through the Janus kinase 2 signaling pathway.62 The degree of hepatic steatosis is inversely correlated with the level of hepatic IGF-1 expression.63 The same correlation was found between nonalcoholic steatohepatitis (NASH) activity score, body mass index, and IGF-1 expression levels.