OCIAD2 and adenocarcinoma: Although the MTTassay showed no significant differences between shScramble controland shOCIAD2 cells (Figure S3B–C), colony formation was markedly reduced in OCIAD2 knockdown cells,indicating that tumorigenesis is obviously suppressed by OCIAD2 knockdown.Furthermore, our results showed that the silencing of the peptidein the cytosolic RNA complex of OCIAD2 inhibits cell migration andinvasion abilities in both A549 (Figure B) and NCI-H322 M cell lines (Figure D), providing a more comprehensiveunderstanding of the cancerous phenotypes associated with OCIAD2 inlung adenocarcinoma.