In breast cancer, SIRT1 modulation by RSV (10–50 μM) paradoxically exhibits dual roles: while SIRT1 overexpression promotes Akt activation, RSV-induced SIRT1 activation at physiologically relevant concentrations (e.g., 25 μM) enhances mitochondrial integrity and apoptosis [38]. This evidence concerns the gene SIRT1 and breast carcinoma.