AKT1 and neoplasm: Cancer remains one of the most formidable global health challenges, with conventional therapies often hampered by systemic toxicity, chemoresistance, and limited therapeutic efficacy against heterogeneous tumor microenvironments (TMEs) [1]. Natural polyphenols, such as resveratrol (RSV), have garnered significant attention for their multitargeted anticancer properties, including modulation of oncogenic pathways (e.g., PI3K/Akt, Wnt/β-catenin), chemosensitization [2], and epigenetic regulation [3].