Critically, in vivo proof-of-concept studies using RSV-loaded invasome gels demonstrate that hydrogel-facilitated delivery significantly amplifies anticancer mechanisms: BAX and Caspase-3 gene expression increased 26-fold and sixfold, respectively, in skin cancer models, correlating with suppressed tumor growth and reduced NF-κB/Bcl-2 pro-survival signaling—effects not achievable with free RSV [122]. The gene discussed is NFKB1; the disease is neoplasm.