SIRT1 and hepatocellular carcinoma: In hepatocellular carcinoma (HCC), RSV (10–100 μM) inhibits PI3K/Akt phosphorylation via SIRT1-mediated deacetylation, with > 50% suppression of p-Akt at 48 h [30, 31], thereby suppressing cell proliferation and migration [32, 33].