The core biomarkers, which are specific to AD pathology, include core 1 biochemical markers such as CSF/plasma levels of Aβ42, p-Tau 217, p-Tau 181, p-Tau 231, and amyloid PET imaging and core 2 tau proteinopathy markers, including CSF levels of microtubule-binding tau fragments (Tau 243, p-Tau 205, and non-phosphorylated mid-region tau) and tau PET imaging. Here, MAPT is linked to Alzheimer disease.