Natural products in psoriasis have an anti-inflammatory effect by blocking important signaling pathways like NF-κB and MAPK pathways, regulating the production of pro-inflammatory cytokines like TNF-α, IL-6, IL-17, and IL-23, and controlling the activity of immune cells like T-helper 17 (Th17) cells. Here, NFKB1 is linked to psoriasis.