ANXA11 and amyotrophic lateral sclerosis: ANXA11 appears to be a pleiotropic gene, as pathogenic variants have been associated with a range of diverse clinical presentations, including corticobasal syndrome [34], childhood-onset oculopharyngeal muscular dystrophy [35], inclusion body myopathy with predominant limb-girdle syndrome [36], semantic variant primary progressive aphasia [37], and ALS with progressive supranuclear features [38].