ANXA11 and amyotrophic lateral sclerosis: In the comparison of ANXA11-ALS with age-, education- and sex-matched C9ORF72-ALS (with a proportion of 1:2), the only test that was significantly more impaired in ANXA11-ALS was Digit Span Forward (FW), while no test was more impaired in C9ORF72-ALS (Table 5).