On multivariable analysis, factors associated with in-hospital death (risk ratio—RR, 95% CI) included ACLF (acute-on-chronic liver failure) (1.73, 1.57–1.90), decompensated cirrhosis (1.31, 1.13–1.51), ALBI (albumin–bilirubin) grade 3 versus 2 (1.65, 1.45–1.87), APACHE-III ICU admission diagnosis of sepsis (1.43 vs. upper gastrointestinal bleeding, 1.24–1.66) or liver failure (1.81 vs. upper gastrointestinal bleeding, 1.55–2.12) and older age. This evidence concerns the gene ALB and Sepsis.