PALB2 and cancer: Individuals at increased risk of specific cancers because of young age at diagnosis or family history of the relevant cancers may be offered panel tests incorporating the genes most often involved in causing such susceptibility, such as a panel including BRCA1, BRCA2, PALB2, RAD51C, RAD51D, PTEN, CDH1 and TP53 for individuals with possible HBOC (Bouras et al.