BRCA1 and cancer: 2022). Epigenetic alterations are thought to be involved in the carcinogenesis process, and the detection of aberrant DNA methylation patterns detected in circulating tumour DNA is being evaluated for the detection of early cancer and treatment responses (Geissler et al. 2024). A test (WID‐qEC) of methylation of the DNA of two genes (ZSCAN12 and GYPC) performed on a cervicovaginal sample is being assessed for the detection of endometrial cancer in women with LS and BRCA1/2 heterozygotes. This test can be self‐administered (Schreiberhuber et al. 2024).