ADIPOQ and amyotrophic lateral sclerosis: Despite previous suggestions of estrogen's neuroprotective role in ALS (51), our additional stratified analysis showed no significant difference in adiponectin levels between premenopausal (n=8) and postmenopausal (n=23) women (57.86 ± 16.66 vs. 54.62 ± 12.52, P = 0.568), indicating that estrogen levels alone likely doesn't explain the sex-based disparity.