To investigate the impact of increased AdipoRs on macrophages inflammation and polarization, we initially measured the expression levels of the prototypical proinfammatory cytokine IL-1β associated with M1 macrophages, and the anti-infammatory cytokine IL-10 associated with M2 macrophages derived from ALS patients. The gene discussed is IL1B; the disease is amyotrophic lateral sclerosis.