NEFL and early-onset autosomal dominant Alzheimer disease: Qaisar et al. (25) showed that serum NfL levels were significantly elevated in patients with COPD, Rosenkranz et al. (26) showed that Alzheimer’s disease and related dementia (ADRD) is more common with asthma, especially when asthma is more severe or worsens more frequently, this suggests an association between sNfL and respiratory disease.