SREBF1 and obesity due to melanocortin 4 receptor deficiency: Elevated glucose levels, ROS, endoplasmic reticulum stress, and inflammatory cytokines also contribute to SREBP1c activation in obesity and T2DM (Sekiya et al., 2008; Uttarwar et al., 2012; Kusnadi et al., 2019; Zhou et al., 2019).