Abnormalities in glycerophospholipid metabolism have been observed in APP/PS1 mice (Qian et al., 2023), where they directly exacerbate AD progression by promoting Aβ deposition and tau protein tangles (Tong et al., 2024), potentially linked to dysregulated gut microbiota and neuroinflammation (Qian et al., 2023; Tian et al., 2022). The gene discussed is MAPT; the disease is Alzheimer disease.