Yingzi He et al. have demonstrated that the inhibition of DNA methylation via the LRP1-PI3K/AKT (Low-Density Lipoprotein Receptor-Related Protein 1 - Phosphoinositide 3-Kinase/Protein Kinase B) pathway can mitigate oxidative stress-induced mitochondrial-dependent apoptosis and ameliorate cisplatin-induced hearing impairment (He et al., 2022). This evidence concerns the gene AKT1 and hearing loss disorder.