In our results we report, for the first time, that STH pretreatment significantly and dose-dependently attenuates STAT3 protein expression remarkably indicating the anti-inflammatory effect of STH that might be due to the inhibition of IL-6/STAT3/TNF-α signaling pathway in CIS-induced nephrotoxicity in CIS-treated rats. This evidence concerns the gene STAT3 and in situ carcinoma.