Previous studies have already detailed the profound increase in renal MDA in addition to a notable decline in GSH level, TAC and SOD activity after CIS injection (Darwish et al., 2017; Abdel-Wahab et al., 2017; Darwish et al., 2018; Ansari, 2017) In contrast to the CIS group, the administration of STH in conjunction with CIS demonstrated protection against oxidative stress in the present study. Here, SOD1 is linked to in situ carcinoma.