Consequently, the current study examined the potential nephroprotective effects of STH on oxidative stress, apoptosis, and inflammation, as well as its impact on the inhibition of the Nrf2/caspase-3 and IL-6/STAT3/TNF-α signaling pathways in CIS-induced nephrotoxicity, at two distinct doses. The gene discussed is STAT3; the disease is in situ carcinoma.