As verified by dual luciferase reporter assay, miR-145-5p inhibited the expression of SOX2 by directly targeting its 3′UTR region, which was negatively correlated with SOX2 in prostate cancer, and the mRNA and protein levels of SOX2 expression were significantly reduced in miR-145-5p overexpressing PCa cells. This evidence concerns the gene SOX2 and posterior cortical atrophy.