As a repressor of EMT and stemness phenotypes, the binding of miR-145-5p in large quantities to lnc-ZNF30-3 diminishes its activity, resulting in the upregulation of TWIST1 and other pro-EMT factors, which subsequently activates EMT and enhances tumor stemness, thereby promoting the migration, invasion, and metastasis of prostate cancer cells (Le Hars et al., 2023). The gene discussed is TWIST1; the disease is prostate cancer.