The HIF2α/VEGF/MMP9/CCND1 signaling in VHL mutant SW-839 and OSRC-2 cells inhibits miR-145 expression, thereby facilitating RCC growth and metastasis (Zheng et al., 2007; Tanaka et al., 2005; Ringel et al., 2006; Roemer et al., 2004). The gene discussed is EPAS1; the disease is renal cell carcinoma.