Gao et al. demonstrated that Tan IIA facilitates cardiac repair in post-MI mice by reprogramming macrophage phenotypes through inactivation of the phosphoglycerate kinase 1 (PGK1)/pyruvate dehydrogenase kinase 1 (PDHK1) pathway and remodeling macrophage energy metabolism (Gao et al., 2024). Here, PDK1 is linked to myocardial infarction.