Chai et al. further elucidated that Tan IIA inhibits cardiomyocyte pyroptosis in a rat HF model following acute MI by down-regulating key inflammatory mediators IL-1β, pro-IL-1β, NLRP3, and caspase-1 through suppression of the TLR4/NF-κB p65 pathway (Chai et al., 2023). Here, IL1B is linked to hydrops fetalis.