This process is amplified by downregulation of GPX4 and FSP1 in MAFLD:GPX4 inhibition: Obesity-induced hyperinsulinemia activates mTORC1, which suppresses NRF2-mediated GPX4 transcription (Sun et al., 2015a). The gene discussed is GPX4; the disease is obesity due to melanocortin 4 receptor deficiency.