The main active ingredient of Cryptochlorogenic Acid (CCA) in mulberry leaf extract may inhibit ferroptosis in diabetic rat models by activating the cystine/glutamate transporter system (XC-)/GPX4/NRF2, inhibit pathways such as NCOA4, and produce a good hypoglycemic effect (Zhou, 2020), suggesting ferroptosis as a therapeutic target of obesity-related metabolic diseases. The gene discussed is NFE2L2; the disease is obesity due to melanocortin 4 receptor deficiency.