HAMP and obesity due to melanocortin 4 receptor deficiency: While ferroptosis mechanisms have been extensively reviewed (Dixon and Olzmann, 2024), this article uniquely focuses on obesity-driven metabolic dysregulation, emphasizing three novel directions: (1) tissue-specific iron overload in adipose tissue and the hepatic system; (2) upregulation of hepcidin mediated by adipokines as a key amplifier of ferroptosis; (3) the dual regulatory role of Traditional Chinese Medicine (TCM) compounds in the modulation of ferroptosis.