Recent studies have revealed that key proteins of the JAK2/STAT3 signaling pathway, including p-JAK2-Tyr1007 and p-STAT3-Tyr705, have been upregulated in the cortex and hippocampus of various AD mouse model (Ni et al., 2023; Long et al., 2021) and that the inhibition of JAK2 can attenuate the increase in inflammatory markers in microglia from APP/PS1 mice (Jones et al., 2015). This evidence concerns the gene JAK2 and Alzheimer disease.