EMT is a key feature of cancer invasion, characte-rized by morphological changes from an epithelial to a mesenchymal phenotype and increased expression of mesenchymal markers (vimentin, N-cadherin, and fibronectin), along with decreased expression of epithelial markers (cytokeratin, E-cadherin, and β-catenin) [60–63]. This evidence concerns the gene CDH2 and cancer.