VEGFA and diabetes mellitus: While DME can be treated by intravitreal injection of anti-VEGF agents or macular photocoagulation (MPC),[7] no approved treatment for DMI exists.[8,9] Several studies have reported the beneficial effects of systemic normobaric oxygen (NBO) therapy on visual function (visual acuity, electroretinography) and retinal structure (OCT, FA) in patients with diabetes.[10,11,12] Moreover, previous studies on NBO therapy in patients with DMI have observed promising results.[13,14]