The GAS6 - TAM pathway was found implicated in carcinoma, inflammation, and haemostasis and has been targeted for the treatment of carcinoma.46, 47, 48 In recent years, there is also evidence that GAS6 plays a role in regulating obesity and lipid metabolism as plasma gamma-glutamyl carboxylated GAS6 (Gla-GAS6) was found significantly lower in hyperlipidaemic individuals compared with healthy controls.49 Here, GAS6 is linked to obesity due to melanocortin 4 receptor deficiency.