After correcting for multiple testing (5% FDR), only genetically predicted CELSR2 had a causal association with CAD (Odds ratio [OR] = 0.64, 95% CI = 0.50, 0.81, FDR = 0.006; Fig. 3A, Supplementary Table S6) which was also supported by strong colocalisation evidence (PPH4 = 93.6%, Fig. 3B, Supplementary Table S7). This evidence concerns the gene CELSR2 and coronary artery disorder.