A locus in the vicinity of CELSR2, rs599839 (in LD with rs660240, the genetic instrument for CELSR2 in this study [r2 = 0.989 in South Asians, r2 = 0.871 in Europeans]), was first reported to be associated with CAD, LDL-C and TC by two GWAS conducted in European ancestry.41, 42, 43 rs660240, a 3' UTR variant, is an eQTL for CELSR2, PSRC1, and SORT1 in liver tissue (Open Target Genetics). This evidence concerns the gene PSRC1 and coronary artery disorder.