TG and anemia: If the Tg-IgA is positive (>10 ULN), HLA DQ2/8 analysis is not recommended in the ESPGHAN guidelines 2020. Due to the variability in presentation, it becomes hard for a clinician to diagnose celiac disease, and hence, all causes of unexplained diarrhea, weight loss, anemia, short stature, enamel issues, and laboratory abnormalities need to be screened for celiac disease.