AARS2- Alanyl-TRNA Synthetase 2; COX8-Combined oxidative phosphorylation deficiency-8; LKENP: Leukoencephalopathy, Progressive, With Ovarian Failure; AR – Autosomal Recessive; Homo – Homozygous; VUS – Variant of uncertain clinical significance; MOI – Mode of Inheritance; NA- Not Applicable; rsID- Reference SNP cluster ID; SIFT - Sorting Intolerant From Tolerant. The gene discussed is AARS2; the disease is Leukoencephalopathy.