Anemia on CBC. Leucocytes dropped during the stay. Normal lymphocyte subsets and NK cells on flow cytometry. The CD4/CD8 ratio was raised. Normal CSF analysis. Normal serum immunoglobulins. Normal BMAT. Brain MRI showed hyperintense lesions in periventricular, subcortical, and cerebellar areas. The gene discussed is CD8A; the disease is anemia (phenotype).