The above study also investigated whether CML stem cells in both mouse models and in cells derived from patients depend on BCR::ABL1 kinase activity for survival and showed that CML stem cell survival was not dependent on BCR::ABL1 activity as demonstrated by the survival of these cells even when BCR::ABL1 was inhibited [44]. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.