Repeated laboratory evaluation revealed ongoing hyperthyroidism (thyroid-stimulating hormone (TSH): 0.02 μIU/mL, fT4 (free thyroxine): 2.39 ng/dL, and primary adrenal insufficiency (adrenocorticotropic hormone (ACTH): 1178 pg/mL, cortisol: <1.5 nmol/L) (Table 1). Here, POMC is linked to Adrenal insufficiency.