Age-related immunodeficiency is believed to be associated with tumorigenesis in diffuse large B-cell lymphoma cells and classical Hodgkin lymphoma and exhibits a high rate of programmed death-ligand 1 (PD-L1) expression in tumor cells, indicating that an immune escape mechanism may play a significant role in its development [4,5]. The gene discussed is CD274; the disease is diffuse large B-cell lymphoma.