GPI deficiency is often overlooked due to its rarity and clinical overlap with other hemolytic anemias (e.g., G6PD deficiency, hereditary spherocytosis); its diagnosis is confirmed through enzyme activity assays and genetic testing, identifying homozygous or compound heterozygous mutations in the GPI gene located on chromosome 19q13.1 [1]. This evidence concerns the gene GPI and hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency.