CYP27A1 and osteoporosis: Secondary outcomes focused on changes in anabolic bone markers, such as bone specific alkaline phosphatase (BSALP), a significant marker of bone formation; osteocalcin, a specific marker for bone matrix synthesis; as well as resorptive markers, including C-telopeptide of type I collagen (CTX) (elevated levels CTX suggest increased bone breakdown, which can be associated with conditions like osteoporosis and osteopenia).