INS and type 1 diabetes mellitus: Insulin dose-adjusted Hemoglobin A1c (IDAA1c), a compound measure accounting for variability in Hemoglobin A1c (HbA1c), insulin requirements and weight, has been used in the management of type 1 diabetes in non CF adults and children to estimate β-cell function, particularly in the honeymoon phase [22,23], and could also be used as a marker of insulin sensitivity.