In their experiment, desensitizing TRPV1 with a desensitizing dose of capsaicin (Oral, 20 mg/kg, Wistar rats), can protect against elevated auditory thresholds caused by noise exposure in rats and downregulate the expression of the inflammatory factor TNF-α, indicates that targeting TRPV1 could be a promising strategy for preventing or treating noise—induced hearing loss. This evidence concerns the gene TNF and hearing loss disorder.