TS, a combination of Cuscutae Semen and Rehmanniae Radix Preparataan, its active ingredients including hyperoside, quercitrin, and kaempferol, can reduce drug and noise-induced hearing loss, potentially by downregulating TRPV1 in HEI-OC1 cells (Hong et al., 2023). The gene discussed is TRPV1; the disease is hearing loss disorder.