The primary aim was to evaluate its impact on macroscopic clinical indicators of colitis severity (DAI, body weight) and to elucidate its potential mechanisms of action by examining its effects on: (1) the expression of growth factors VEGF and EGF in colonic tissue; (2) systemic and local inflammatory cytokine profiles (TNF‐α, IL‐6, IL‐10); (3) the balance of total oxidants and antioxidants in colonic tissue; (4) the activation state of the central PI3K/AKT signaling pathway; and (5) the expression of key apoptotic markers (Bax, Bcl‐2, Caspase‐9, Caspase‐3, Cytochrome c). This evidence concerns the gene TNF and colitis.