UV‐C inactivated Lacticaseibacillus casei 39 paraprobiotic suppressed inflammation (↓TNF‐α, IL‐6; ↑IL‐10), oxidative stress (↓TOC, ↑TAC) and apoptosis (↓Bax/Bcl‐2, ↓Caspase‐3/9, ↓cyt c) in an acetic acid‐induced colitis model. Here, IL6 is linked to colitis.