INF2 mutations are strongly associated with both isolated FSGS and Charcot-Marie-Tooth neuropathy, while FN1 mutations have been linked to glomerulopathy with fibronectin deposits.3 Although these VUS are not definitively pathogenic, their presence raises the possibility of an underlying genetic predisposition that may have contributed to disease progression. This evidence concerns the gene FN1 and Charcot-Marie-Tooth disease, axonal, type 2FF.