INF2 mutations are strongly associated with both isolated FSGS and Charcot-Marie-Tooth neuropathy, while FN1 mutations have been linked to glomerulopathy with fibronectin deposits.3 Although these VUS are not definitively pathogenic, their presence raises the possibility of an underlying genetic predisposition that may have contributed to disease progression. The gene discussed is INF2; the disease is glomerular disorder.