To align with the current U.S. National Institutes of Health policy’s emphasis on the evaluation of sex as an important biological variable, the present study design incorporated adult rats of each sex to investigate the corollary notion that Ghrh-R may exert sex-dimorphic control of eu- and/or hypoglycemia-associated counterregulatory hormone profiles and VMNdm Ghrh neuron counterregulatory neurochemical marker gene expression. Here, GHRHR is linked to Hypoglycemia.