Evidence that Ghrh regulation of distinctive counterregulatory transmitter marker gene profiles is reliant upon systemic glucose profiles, i.e., is gained or lost by induction of insulin (INS)-induced hypoglycemia (IIH), infers that this neuropeptide signal may coordinate VMNdm Ghrh neuron transmission output during glucose dyshomeostasis [16]. The gene discussed is GHRH; the disease is Hypoglycemia.