About 2–3% of cases are familial, and several RCC-related genes have been described, including VHL, PBRM1, TSC1/TSC2, FLCN, BAP1, FH, STED2, JARID1c/KDM5C, and MTOR [4,5,6,7,8]. This evidence concerns the gene KDM5C and renal cell carcinoma.