It is intriguing to speculate that this may be relevant for the roles of VE-PTP and Tie-2 for determining vessel diameter during development (Baumer et al., 2006; Dominguez et al., 2007; Winderlich et al., 2009) and the role of Tie-2 in venous malformations (Vikkula et al., 1996; Wouters et al., 2010; Natynki et al., 2015), a concept which will be interesting to study in more detail in the future. This evidence concerns the gene TEK and Venous malformation.